This makes it impossible to legitimately obtain the Pimp-Boy 3 Billion.
However, if the Courier picks up the note, they will NOT be able to free Troike from his contract. The Courier can find evidence of foul play by looking for the blackmail note in a safe in Big Sal's office that proves the bosses set Troike up. When talking to him, the Courier can choose a 30 Medicine check, saying that the story he tells the Courier about blacking out does not make sense. Troike is found in the lower Brimstone level. Inside is a hooker's corpse, which the Courier can inspect with 35 Medicine. His room key that unlocks the safe also unlocks the door to the 100 Lockpick maintenance room (on the same suite level to the west). Alternatively, the Courier can choose to keep the tapes, at which point he will become hostile and attack them. A 50 Barter check makes him leave after giving the player character 200 caps. Telling Clanden that the Courier has the tapes gives them the option of telling him to leave and never come back. The Courier can take the evidence back to Cachino, who will give them the option to confront Clanden with the tapes, or the Courier can just confront Clanden with them. Alternatively, the Courier can steal Clanden's key off him, which opens a safe behind the dresser next to his bed, or they can just pick the safe's lock if they have at least 75 Lockpick skill. If the Courier goes back and speaks to Cachino, he will mention he did some asking around and the bosses' plans would be screwed if Clanden was not around, so he asks the Courier to kill Clanden discreetly. He will not give the Courier any clues or talk with them about what he does at all, even if the Courier mentions that Cachino sent them. Take the elevator to the suites level to find Clanden. He tells the Courier about two people in the club who were hired by the bosses as part of their plans and says to talk to Clanden and Troike about specifics. Once the Courier confronts Cachino with his journal, he will give them 100 caps to get the journal back a 60 Barter check makes him give the Courier an additional 200 caps. (The Courier can pay her the 300 caps, then pickpocket her to get it back.) Alternatively, the Courier can just pickpocket Cachino since he is carrying a copy of the journal. The Courier can get the key to his suite from the receptionist either by paying 300 caps, passing a 8 Strength check (making it free of charge,) or passing a 55 Barter check which lowers the bribe to 200 caps. There is a journal in his desk directly to the left as the Courier enters the bedroom of his suite, and another on his person that can be pickpocketed this is the evidence needed. The Family does not know about this work because it goes against Omerta rules, putting his life at risk if it ever gets out. Once the Courier meets him, they need to find proof of Cachino's work he's been pulling on the side.
The Courier's inquiries will prompt Cachino to approach them when they enter the Brimstone club. Having the Confirmed Bachelor and/or Terrifying Presence perks gives the Courier additional speech options for the same result. They will be unfriendly to this and not answer, but Cachino will still turn up after this. The Courier can ask a few of the dealers/bouncers/hookers for Cachino's whereabouts. If she has a Speech option for the Courier to ask her information about "the outstanding balance," she can point the Courier to Cachino, a low-level lieutenant. Once the quest starts, the Courier can talk to the receptionist in the main entrance of Gomorrah. The Courier can also automatically receive this quest upon accepting The House Always Wins IV from Mr. She will then tell the Courier to talk to Liza O'Malley to start this quest. In For the Republic, Part 2, the Courier will be asked to get some information regarding the Omertas by Colonel Moore. Otherwise, the Courier will have to return to Yes Man and opt to ignore the Omertas, if they've given up finding clues.
If the Courier is going to do the Wild Card quests, make sure to ask him about the Omertas, so that new speech options progress the quest when exploring Gomorrah. This quest can also be activated after talking to Yes Man. He mentions that the Omertas have stopped buying guns from him without a word as to why. This quest can be given by Mick at Mick & Ralph's after asking him for work. Finally, completing this quest incorrectly prevents the player character from acquiring the Pimp-Boy 3 Billion.
Also, If the Courier does not speak to Liza O'Malley before starting How Little We Know, they will not be able to complete For the Republic, Part 2 see Bugs below.
It is best taken after completing Bye Bye Love, as completing this quest will render Bye Bye Love either unobtainable or unable to be completed. Warning: It is tricky to avoid permanently locking options in this quest.